DENGUE HEMORRHAGIC FEVER (DHF) AND THE CRITICAL
PHASE: BE AWARE OF THE CONDITION WHEN THE FEVER
STARTS TO SUBSIDE
Written by. Xena Calista
− “Decrease in fever does not always indicate recovery. In Dengue Hemorrhagic Fever, the
critical phase may actually begin when the body temperature returns to normal." −
Dengue Hemorrhagic Fever (DHF) is an infectious disease caused by the dengue virus
and transmitted through the bites of infected mosquitoes, particularly Aedes aegypti. This
disease remains a major public health concern in many tropical and subtropical countries,
including Indonesia. DHF can affect anyone regardless of age, from children to adults. The
severity of the disease also varies, ranging from asymptomatic infections and mild symptoms
to severe conditions that can be life-threatening if not properly treated (WHO, 2009).
The dengue virus has four main serotypes, namely DENV-1, DENV-2, DENV-3, and
DENV-4. A person can experience dengue infection more than once because the immunity
developed after being infected with one serotype does not provide complete protection against
other serotypes. Repeated infection with a different serotype may increase the risk of
developing severe dengue in some patients. Therefore, individuals who have previously
experienced DHF remain at risk of being infected again (CDC, 2026).
Symptoms of DHF generally appear after the virus has undergone an incubation period
of several days. Patients usually experience a sudden high fever, headache, pain behind the
eyes, muscle and joint pain, nausea, vomiting, and the appearance of reddish spots on the skin.
However, symptoms may vary from person to person, so medical examinations are necessary
to confirm the patient's condition. Understanding this disease is important so that the public
does not consider ordinary fever as the only symptom that needs attention (WHO, 2009).
Dengue virus transmission occurs through mosquitoes that act as disease vectors. Aedes
aegypti is one of the main vectors responsible for transmitting DHF to humans. These
mosquitoes generally breed in clean water containers that are left uncovered, such as bathtubs,
buckets, drums, flower vases, and discarded objects that can collect water. Environmental
conditions with numerous mosquito breeding sites can increase the risk of dengue transmission
within communities (WHO, 2009).
Aedes aegypti mosquitoes have physical characteristics consisting of black bodies with
white stripes on their legs and body parts. Female mosquitoes feed on human blood to support
the development of their eggs. When a mosquito bites someone who is infected with dengue,
the virus can enter the mosquito's body and multiply before eventually being transmitted to
another person through subsequent bites. Therefore, the presence of infected mosquitoes is an
important part of the chain of DHF transmission (WHO, 2009).
DHF transmission is also influenced by environmental conditions and community
behavior. The habit of leaving water storage containers uncovered, accumulating discarded
objects, and paying insufficient attention to environmental cleanliness can create suitable
breeding sites for mosquitoes. Therefore, mosquito control is not only the responsibility of
healthcare workers but also requires community involvement in maintaining the cleanliness of
residential environments.
Symptoms of DHF may appear suddenly after the dengue virus enters the body and
passes through its incubation period. Fever is one of the most common symptoms, usually
accompanied by headaches, muscle pain, joint pain, nausea, vomiting, and skin rashes. Some
patients may also experience mild bleeding, such as nosebleeds, bleeding gums, or red spots
on the skin. These symptoms may resemble those of other infectious diseases, making medical
examinations necessary to establish an accurate diagnosis (CDC, 2026).
The progression of DHF does not always follow the same pattern in every patient. Some
individuals may experience mild symptoms and recover without complications, while others
may experience worsening conditions. One important aspect to consider is the change in body
temperature throughout the course of the disease. When the fever begins to subside, patients
should not immediately be considered recovered because this period may coincide with the
beginning of the critical phase (WHO, 2009).
In general, the clinical progression of dengue infection is divided into three phases: the
febrile phase, the critical phase, and the recovery phase. Each phase has different characteristics
and risks. Understanding these phases is essential so that patients and their families can
recognize changes in the patient's condition and know when to seek medical attention
immediately (CDC, 2026).
The febrile phase is the initial stage of DHF, which generally lasts for 2–7 days. During
this stage, patients experience an increase in body temperature that may reach 40°C. The fever
usually appears suddenly and may be accompanied by headaches, pain behind the eyes, muscle
and joint pain, nausea, vomiting, and skin rashes. Some patients may also experience a
decreased appetite and weakness, which can interfere with their daily activities (CDC, 2026).
During this phase, patients need to pay attention to adequate fluid intake because fever
and vomiting can increase the risk of dehydration. In addition, their physical condition needs
to be monitored regularly to identify the possible appearance of warning signs. Medical
examinations at healthcare facilities are important when dengue infection is suspected,
particularly if the fever is accompanied by other symptoms indicating DHF. Early management
can help reduce the risk of delays in recognizing disease progression (Ministry of Health of the
Republic of Indonesia, 2020).
The critical phase is the stage that requires the greatest attention during the progression
of DHF. This phase usually begins when the patient's body temperature starts to decrease or
returns close to normal, generally around the third to seventh day after the onset of fever. The
critical phase lasts approximately 24–48 hours. During this period, some patients may
experience increased vascular permeability, which causes blood plasma to leak from the blood
vessels into surrounding tissues or body cavities (WHO, 2009; CDC, 2026).
This condition can cause a decrease in the volume of blood circulating within the blood
vessels. As a result, blood flow to vital organs may become impaired if plasma leakage becomes
severe. If not treated immediately, patients are at risk of developing dengue shock, respiratory
problems due to fluid accumulation, severe bleeding, and even organ dysfunction. Therefore,
the critical phase requires careful monitoring of clinical conditions and laboratory examinations
(WHO, 2009).
A common misconception among the public is the belief that a decrease in fever indicates
that the disease has been cured. In fact, in DHF, a decrease in body temperature may signal the
beginning of the critical phase. Not all patients will experience severe complications, but this
period must still be closely monitored because changes in the patient's condition can occur
rapidly. Therefore, monitoring should not be discontinued simply because the patient's body
temperature has returned to normal (CDC, 2026).
The recovery phase is the stage when the patient's condition begins to improve after
passing through the critical phase. During this phase, fluid that previously leaked from the
blood vessels is gradually reabsorbed into the bloodstream. The patient's general condition
usually improves, appetite begins to increase, and physical activities gradually return to normal.
The white blood cell count generally begins to increase first, followed by an increase in the
platelet count (CDC, 2026).
Although the patient's condition begins to improve, monitoring is still necessary to ensure
that the recovery process proceeds properly. One aspect that must be considered is fluid
administration during treatment. Excessive fluid administration when body fluids begin
returning to the bloodstream can cause fluid overload. This condition may lead to
complications, including respiratory problems. Therefore, fluid management must be based on
an assessment by healthcare professionals (WHO, 2009).
Dengue Hemorrhagic Fever is an infectious disease caused by the dengue virus and
transmitted through the bites of infected mosquitoes. This disease has three phases of
progression: the febrile phase, the critical phase, and the recovery phase. Among these three
phases, the critical phase requires special attention because plasma leakage may occur,
potentially leading to decreased blood volume, dengue shock, severe bleeding, and organ
dysfunction.
An important point that the public needs to understand is that a decrease in fever does
not always indicate that the patient has recovered. During this period, patients require further
monitoring to identify the possible appearance of warning signs. Medical examinations,
appropriate treatment, and family awareness in monitoring changes in the patient's condition
are essential in preventing DHF complications.
In addition to patient management, prevention through the 3M Plus movement must be
carried out regularly and continuously. Maintaining environmental cleanliness, eliminating
mosquito breeding sites, and increasing public knowledge about DHF are important measures
in reducing the risk of transmission. Therefore, DHF prevention and management require
cooperation among individuals, families, communities, and healthcare professionals.
Reference:
Centers for Disease Control and Prevention. (2025, August 26). Clinical testing guidance for
dengue. https://www.cdc.gov/dengue/hcp/diagnosis-testing/
Centers for Disease Control and Prevention. (2026, April 15). Clinical care of dengue.
https://www.cdc.gov/dengue/hcp/clinical-care/
Centers for Disease Control and Prevention. (2026, February 24). Clinical features of dengue.
https://www.cdc.gov/dengue/hcp/clinical-signs/index.html
Kementerian Kesehatan Republik Indonesia. (2019, June 13). Upaya pencegahan DBD dengan
3M Plus. https://ayosehat.kemkes.go.id/upaya-pencegahan-dbd-dengan-3m-plus
Kementerian Kesehatan Republik Indonesia. (2020). Keputusan Menteri Kesehatan Republik
Indonesia Nomor HK.01.07/Menkes/9845/2020 tentang Pedoman Nasional Pelayanan
Kedokteran Tata Laksana Infeksi Dengue pada Dewasa.
https://jdih.kemkes.go.id/documents/keputusan-menteri-kesehatan-nomor-
hk0107menkes98452020
World Health Organization & Special Programme for Research and Training in Tropical
Diseases. (2009). Dengue: Guidelines for diagnosis, treatment, prevention and control.
World Health Organization. https://www.who.int/publications/i/item/9789241547871